Intellectual Developmental Disabilities Research Center

2018 IDDRC Projects and Supporting Cores

 

Principal
Investigator
Grant Number and Title Clinical Translational Core Genetics Core Translational Neuroscience Core Neuroimaging Core Behavior Science Core
Aggarwal R21NS096249-01A1: Oscillating Gradient Diffusion MRI and Quantitative Susceptibility Mapping in the Epileptogenic Brain X
Atkinson UL1-TR001079 (NBRU): Chronic Kidney Disease in Chldren Study (CkiD) X
Bastian R01 HD040289: Mechanisms and Rehabilitation of Cerebellar Ataxia X
Baumgartner R01 HL091541: Excitotoxicity in circulatory arrest-brain injury X
Bembea K23 NS076674: Novel methods of Brain Injury Detection and Outcome Prediction in Pediatric ECMO X
Bjornsson DP5 OD017877: Clinical Confirmation of Novel Computational Genetic Elements X
Bjornsson DP5 OD017877: Exploring Kabuki Syndrome as a treatable cause of intellectual disaiblity X
Blue/Kannan R21 NS100085: Dendrimer Therapies for Treatment of Rett Syndrome X X
Brasic JHUSM BriteStar Award: The Feasibility Study of Metabotropic Glutamate Receptor Type 5 Function in Fragile X Syndrome X
Budimirovic Ovid Therapeutics, Inc.: A Phase 2a, Randomized, Double-Blind, Parallel-Group, Proof-of-Concept Study Evaluating the Safety, Tolerability, and Efficacy of OV101 in Fragile X Syndrome X
Burd K08 HD073315: IL-1β Regulation of Perinatal Brain Injury X X
Capone UL1-TR001079 (NBRU): Depression and Sleep Disorders in Adolescents and Young Adults with Down syndrome X
Carnell UL1-TR001079 (NBRU): Neurobehavioral Influences on Body Weight X
Cayton Vaught Edward E. Wallach Research Fellowship Grant and UM1 HG006542: Demystifying Unexplained Recurrent Pregnancy Loss Through Next Generation Sequencing Technologies X
Celnik R01 HD053793: Novel Strategies to enhance motor function after stroke X
Celnik R01 HD073147: Understanding motor behavior after stroke X
Cheng K01 AA020873: Neuroimaging of Eyeblink Conditioning in Subjects with Alcohol Use Disorders X
Comi Faneca 66 Foundation: Cannabidiol expanded access study in medically refractory Sturge-Weber syndrome X
Comi Faneca 66 Foundation: Trial of sirolimus for cognitive impairments in Sturge-Weber syndrome X
Cutting R01 DK044003: Molecular genetics of cystic fibrosis: Creation and characterization of an airway epithelial cell line for stable expression of exogenous genes X
Edden Brian’s Hope Foundation: Nanodendrimer-Based Targeted Delivery of the N-Acetylcysteine for Adrenoleukodystrophy: A Pilot Study to Determine Feasibility of Clinical Translation X
Edden UL1-TR001079 (NBRU): Dysfunction of Sensory Inhibition in Autism X
Ehsani Hopkins Science of Learning Institute: Neurophysiological Measures of Hazard Perception Among Novice and Teenage Drivers X
Everett R01 HD68446: GFAP Biomarker of Whole Body Cooling Outcome and Efficacy in the Neonate with HIE X X
Ewen R21 NS091569: Direct Examination of Imitation Based Learning in ASD X X X
Fatemi R01 NS097511: Targeted Therapies for Neonatal White Matter Injury X X
Fatemi Brian’s Hope Foundation: Nanodendrimer-Based Targeted Delivery of the N-Acetylcysteine for Adrenoleukodystrophy: A Pilot Study to Determine Feasibility of Clinical Translation X
Fatemi A Cure for Ellie Foundation: Characterization of the Natural History of Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation X
Findling R01 MH073967: Longitudinal Assessment of Manic Symptoms X X
Findling NCT02674633: Software Treatment for Actively Reducing Severity of ADHD (STARS-ADHD) X
Findling Supernus Pharmaceuticals, SPN810P301: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Molindone Hydrochloride Extended-Release Tablets for the Treatment of Impulsive Aggression in Pediatric Patients with Attention Deficit/Hyperactivity Disorder (ADHD) in Conjunction with Standard ADHD Treatment Objectives X X
Findling Dasotraline Pediatric Extension Study X
Findling Safety and Tolerability Study of SPD489 in Preschool Children Aged 4-5 Years, Diagnosed With Attention-deficit/Hyperactivity Disorder X
Germain-Lee R21 HD078864: The Role of G Protein-Coupled Signaling in Neurocognitive and Psychosocial Abnormalities X
Hagopian R01 HD076653: Delineating subtypes of self-injurious behavior maintained by automatic reinforcement X
Hardwick R01 NS083373: Mechanisms of Neurodegeneration X
Harris Rubenstein Taybi Syndrome Foundation: Characterizing the Neurocognitive and Neurophysiologic Phenotype of Rubinstein-Taybi Syndrome X X X
Hoover-Fong/Gunay-Aygun 03-HG-0264, NCT00068224: Clinical and Molecular Investigations into Ciliopathies X
Jacobson PCORI Research Institute: Surviving Cancer, Thriving in Life: Health-related Quality of Life after Pediatric Cancer X
Jacobson PCORI Research Institute: Surviving Cancer, Thriving in Life: Health-related Quality of Life after Pediatric Cancer X
Johnson U01 NS038455: Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) X
Johnston 2K12 NS001696: Neurology Sciences Academic Development Award (NSADA) X X
Johnston Kennedy Krieger Institute-Johns Hopkins Medicine Interdisciplinary Cerebral Palsy (CP) Center of Research Excellence (KKI-JHM CPCRE): Nanomedicine-Based Therapy for Perinatal White Matter Injury X X X
Kadam R01 HD090884: Mechanisms Regulating KCC2 Hypofunction During Refractory Seizures in a Mouse Model of Ischemic Neonatal Seizures X
Kamiya/Pletnikov R01 DA041208: Molecular Mechanism of Astrocytic Vulnerability to Adolescent Cannabis Use      X
Kannan R01 HD069562: Mechanisms and Novel Therapy in Intrauterine Inflammation Induced Brain Injury X
Kannan R01 NS093416: Targeting Glutamate Carboxypeptidase in Perinatal Brain Injury X X
Keefer Private Donor: A Pilot Investigation of a Novel Child/Parent Mindfulness Intervention to Improve Emotional Dysregulation in Children with Autism Spectrum Disorders X
Krinsky-McHale/Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome.  Subproject 2: (8402) Validation of Criteria for Identifying “MCI” in Adults with Down syndrome. X X
Lance 1K23HL133455: Neuroimaging, Protein Biomarkers, and Neurodevelopment in Very Young Children with Sickle Cell Disease X X X
Landa R01 MH059630: Autism social and communication predictors in siblings X
Laterra R01 NS076759: Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9 X
Laterra R01 NS096754: Chromatin Modifications in GBM-Propagating Cells X X
Lee R01 NS093213: Cell extrinsic factors’ roles on direct conversion to human induced neural crest X
Li R35 GM118172: Cellular Dynamics in Division, Motility, and Evolutionary Adaptation X
Lin UL1-TR001079 (NBRU): Noninvasive imaging and functional correlation of intracranial pial angiomatosis (SWS) X
Maegawa R01 NS079655: Development of an HTS assay for a neurological lysosomal disease X
Mahone R01 HD068425: Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates X X
Mahone UL1-TR001079 (NBRU): DNA Methylation in Children with ADHD and/or Dyslexia X
Mahone Maryland State Department of Education (MSDE): Improving Equity in Access and Opportunity for Students with Disabilities X
Mahone Maryland State Department of Education (MSDE):  School-Based Uses of Applied Behavior Analysis: Open Online Modules for Teachers, Administrators, and Special Education Student Support Staff X
Mahone Department of Education (DOE): Neuroscience of Learning and the Learner X
Meador U01 NS038455: Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) X
Miller R01 EB020062:  Neurogenerative and Neurodevelopmental Subcortical Shape Diffeomorphometry X X
Moler U01 HL094345: Therapeutic Hypothermia After Pediatric Cardiac Arrest: A Randomized Controlled Trial (THAPCA) X X
Mostofsky R01 MH078160: 1/2 Anamalous Motor Physiology in ADHD X X
Mostofsky R01 MH085328: Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD of deficient response control in ADHD X X
Mostofsky/Gilbert R01 NS096207: GABAergic Sensorimotor Dysfunction in Tourette Syndrome X X
Naidu R01 FD004247: PH2 Study of dextromethorpan in the treatment of Rett syndrome X X X X
Nebel K01MH109766: Visual-Motor Development in Infants at High Risk for Autism X
Northington R01 HD070996: Mechanisms of hypothermic neuroprotection in neonates X X
Pelled R01 NS072171: The role of transcallosal pathway to neuroplasticity following nerve injury X
Pevsner U01 MH106884: Role of somatic mosaicism in autism, schizophrenia and bipolar disorder brain X
Pevsner UL1-TR001079 (NBRU): DNA in Children with Developmental Disabilities X
Pletnikov R01 MH083728: DISC1 in Neuron-Astrocyte Interactions in Neurodevelopment  X
Pritchard R03 EB023359: Role of Peripheral and Brain Iron in the Development of Attention and Cognitive Control X X
Puts K99 MH107719: A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum Disorder X
Reeves R01 HD038384: Genomic Approaches to Aneuploidy X
Reti R21 HD092915: Neuromodulation Treatment for Self-Injurious Behavior Associated with Intellectual and Developmental Disabilities X
Robertson 5U01NS081041-02: Approaches and Decisions in Acute Pediatric TBI (ADAPT) X
Rosch K23 MH101322: Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates X X
Ruble/Jacobson Saint Baldrick’s Foundation: Sleep and Neurocognitive Outcomes in Childhood ALL Survivors X
Sadowsky Ekso Bionics, 105333: Adherence to Home-Based Functional Electrical Stimulation (FES) Exercise in Patients with Spinal Cord Injury (SCI) X X
Salpekar NCT03371836: Use of Clobazam in Treating Anxiety Comorbid with Pediatric Epilepsy X X
Scafidi K08 NS069815: Metabolic dysfunction and neuroprotection after pediatric head injury X
Schupf/Lott/Silverman U01 AG051412: Biomarkers of Alzheimer’s disease in adults with Down syndrome X X X X
Schupf/Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome. Subproject 4: (8404) Genetic Epidemiology of Alzheimer’s Disease in Down syndrome X
Seymour K23 MH107734:  Neurobehavioral correlates of frustration in ADHD X X
Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome X
Singer Tourette Association of America (TAA): Home-based Behavioral Intervention for Tics, Comparison of Home-based DVD Therapy and Psychologist-directed CBIT Treatment X
Song Tourette Association of America (TAA): Home-based Behavioral Intervention for Tics, Comparison of Home-based DVD Therapy and Psychologist-directed CBIT Treatment X
Suskauer UL1-TR001079 (NBRU): Neural Basis of Impairments in Response Inhibition and Processing Speed X
Suskauer R01 HD090266: Subtle Motor Functioning and Functional Connectivity in Youth Medically Cleared After Mild TBI X X
Tifft NHGRI Rare Impact Award: Diagnosis and Segregation of Undiagnosed Disease X
Tycko/Silverman P01HD035897: Aging and dementia in adults with Down syndrome. Subproject 3: (8403) Epigenetic Modifiers in Down syndrome X
Valle UM1 HG006542: Baylor-Johns Hopkins Center for Mendelian Genetics X X
Vernon K08HD073492: Metabolic studies in disorders of branch chain amino acid metabolism X X
Wagner U54 HD060848: Biomarkers for Therapy of FSHD X
Wagner NCT01847573: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of HT-100 in Duchenne Muscular Dystrophy X
Wang R21NS085358: DHHC 15 palmitoylation modulates striatal dopamine system X
Watkins R21NS091988: Drug Discovery for X-Linked Adrenoleukodystrophy X X
Watson 5R01 HD074757: Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood X
Wilson U54HD079123: IDDRC Research Component (6271): Multi-modal Treatment for Neonatal HIE: Hypothermia and Dendrimer Nanotherapy X X X
Wu R21NS098018: In-Utero Characterization of Embryonic Mouse Brain Development and Injury with MRI X
Xia 5R01NS091165: Effect of IDH1 Mutation on Chromosome Instability X X
Yau R01EY014596: Melanopsin Photoreception and Signaling X
Zhang R01HD074593: Imaging neonatal hypoxic ischemic injury X